High Fiber diet and regulation of oncogenes Research Paper

High Fiber diet and regulation of oncogenes - Research Paper Example Statistics reflecting the estimated cases of cancer and deaths caused by cancer in the United States have also been taken into account, so as to further strengthen the relevance of the topic. Oncogenes are proto-oncogenes turned bad -- genes that have undergone mutations (American Cancer Society, 2011); mutations are changes in the makeup of a gene’s building blocks, DNA (American Cancer Society, 2011). According to the theory of gene mutation, carcinogen interaction with deoxyribonucleic acid leads to irrevocable genetic changes (Devi, 2005, p. 18). Even a minute alteration in the arrangement of these building blocks can create a strong negative impact (American Cancer Society, 2011). Normally, proto-oncogenes are responsible for the encoding of proteins, which promote cell division and impede cell differentiation (Chial, 2008). On the other hand, these mutated proto-oncogenes â€Å"typically exhibit increased production of these proteins, thus leading to increased cell division, decreased cell differentiation, and inhibition of cell death† (Chial, 2008). The aforementioned process leads to cancer (Chial, 2008); hence, there is a need to regulate these onc ogenes. A â€Å"diet high in fiber† is made known to have a considerable impact in the shrinking of predisposition to â€Å"colorectal cancer† (Doheny, 2011). Doll and Peto were the first to highlight the existence of a link between diet composition and cancer -- an example of which is high-fiber diet and its effectivity in chemoprevention (as cited in Devi, 2005, p. 21). Carcinogenesis begins with initiation as normal genes are exposed to carcinogens (Devi, 2005, p. 16). After which, promotion follows -- a stage wherein the gene is repeatedly exposed to stimuli (Devi, 2005, p. 17). Thereafter, progression occurs; this is the proliferation of the mutated gene (Devi, 2005, p. 17). Devi

Developmental Apraxia Symptoms, Causes, and Treatments Essay Example for Free

Developmental Apraxia Symptoms, Causes, and Treatments Essay Apraxia of speech is a neurological condition in which a person finds it impossible to move their mouth or tongue to speak (Apraxia, 2005). There are two main types of apraxia; they are acquired apraxia of speech and developmental apraxia of speech (Apraxia of Speech, 2002). This paper is about Developmental Apraxia of Speech, its symptoms, causes, and appropriate treatments. Developmental apraxia of speech is also called childhood apraxia of speech, because it is present from birth (2002). There are many symptoms of developmental apraxia, and each child may have different symptoms (Childhood, 1997). Some symptoms of very young children include problems eating, not cooing as an infant, late first words, problems combining sounds, and deleting difficult sounds and replacing them with easier ones more often than normal children (1997). In older children, symptoms can include making inconsistent sound errors, understanding of language better than their ability to talk, difficulty imitating speech, difficulty saying long phrases or words clearly, difficulty for others to understand their speech, and speech which sounds choppy or monotonous (1997). Other symptoms may include delayed language development, word order confusion, word recall issues, difficult fine motor development and coordination, over sensitivity or under sensitivity of the mouth, and trouble reading, writing, and spelling (1997). Because there are so many possible symptoms of developmental apraxia, it is important to have children evaluated by a professional to rule out other causes of speech problems (1997). Developmental apraxia is believed by many researchers to be a neurologically based speech-motor disorder, but exact causes have not been isolated (Causes of Apraxia, 2010). Researcher’s studies have not shown a difference or abnormalities in the brains of children with developmental apraxia (2002). Children with developmental apraxia often have family members with learning disabilities or communication disorders (2002). Researchers continue to conduct studies to find any brain abnormalities and genetic factors which may cause developmental apraxia (2005). Speech language therapy is used for treating developmental apraxia. Intensive intervention which begins early is best for children with this disorder (Lederman, 2012). In the beginning, children should have treatment 3-5 times per week (1997). Children diagnosed with developmental apraxia show improvement more quickly when they receive treatment individually (1997). Speech language therapy for children with developmental apraxia differs from the therapy of children with other language disorders (2012). Treatment is based on the principles of motor learning, including repetition to establish and develop motor plans, practice opportunities to maintain learned patterns, use of relevant words and phrases, increased sensory feedback, and work on sound and word sequences (2012). There are still many things to learn about developmental apraxia, and studies regarding causes and treatments are still ongoing (2002). There is also research being done to find more specific criteria to identify and diagnose developmental apraxia and to distinguish it from other communication disorders (2002). References American Speech-Language-Hearing Association. Childhood Apraxia of Speech (1997). www.asha.org/public/speech/disorders/childhoodapraxia.htm Lederman, D. (2012). Speech Language Therapy for Childhood Apraxia of Speech. www.donnalederman.com/disorder-types/apraxia-of-speech.php National Institute on Deafness and Other Communication Disorders. Apraxia of Speech (2002). www.nidcd.nih.gov/health/voice/pages/apraxia.aspx University of Rochester Medical Center. Causes of Apraxia (2010). www.urmc.rochester. edu/speech-pathology/speech-language-disorders/apraxia/causes-apraxia.cfm Web MD. Apraxia: Symptoms, Causes, Tests, Treatments (2005). www.webmd.com/ Brain/apraxia-symptoms-causes-tests-treatments

A TV Show that is Appropiate for a Younger Audience :: Free Essay Writer

A TV Show that is Appropiate for a Younger Audience Wishbone: A Little Dog with a Big Imagination â€Å"Printed Paws of Thieves" With his uncanny knowledge of famous authors, a little dog-named Wishbone is one very smart canine. The Wishbone television series has been created to introduce children to classic literature and encourage a love for reading books. The half-hour, live-action series, designed primarily for elementary school children between the ages of 6 and 12, represents an entirely new concept in educational programming. As children watch Wishbone the dog’s adventure in the world of literature, they will come away with their first taste of classic literature as well as a desire to learn more. The series stars Wishbone the dog, â€Å"a little dog with a big imagination,† who serves as a canine bridge between life and literature. Portrayed in the series by a real Jack Russell terrier, Wishbone the dog represents an articulate, clever and funny character, whose every thought, is heard by the audience. Each episode presents a different literary classic, introduced through Wishbone the dog’s active imagination and fantasies. For example in the episode â€Å"Printed Paws of Thieves† which presents the story of Robin Hood, Joe Talbot the 12-year old owner of Wishbone almost gets suspended when he helps the school lunch lady donate leftover food to a local shelter. Meanwhile, Wishbone as Robin Hood risks arrest when he robs from the rich to give to the poor. In this episode, Wishbone is wearing the typical outfit we think of Robin Hood wearing a Brown leather two-piece outfit carrying a bow and arrow and a feathered cap. Wishbone portrays the character, Robin Hood as if how we would perceive him in the classic literature story. Throughout this episode Wishbone and the other characters, Joe Talbot, David (Joe’s best friend), and Samantha (a neighborhood friend of Joe’s and David’s), reinforce the primary literary themes explored in â€Å"Robin Hood.à ¢â‚¬  Wishbone the dog represents the imaginative, playful child inside all of us. Through his wild adventures and heroic stunts, children will be introduced to some of the greatest literary works of literature. This PBS series provides a challenge for children to read, by providing signature scenes, the basic characters, and themes from classic literature without presenting the entire story so children will want to learn more about the story. It provides a foundation for the children to apply what they already know about the story from the Wishbone series to the actual classic literary form of the story so they will comprehend the story better.

Essay --

The Effects of Revenue Management in the Hospitality Industry Up until recent years Revenue Management was something that has never been heard of. Now days, it is something that hotel managers cannot go without. They spend numerous amounts of time checking their computers for the nightly rates of the hotel. But what exactly is Revenue Management? â€Å"Revenue Management (RM) is a scientific technique that combines Operations Research, Statistics and Customer Relationship Management and categorizes customers into price bands, based on various services† (Revenue Management, 2010). In other words someone might reserve a room that is at a going rate of $245 per night while their cousin who reserved a room at the same hotel months in advance only has to pay $105 per night. Now you may ask yourself how hotels can get away with doing this? But what it all boils down to is that someone who reserves a room last minute will end up paying the higher amount because his or her demand for the room is higher. This technique of raising or lowering prices based on the demand of the guest is something that airlines have been using for some time now. The first two airlines to use Revenue Management in 1985 were United and American Airlines. They used a series of algorithms to determine the best price to sell their seats (Desiraju & Shugan, 2000). The reason Revenue Management came about in the airline industry had to do with the airplanes only having a select amount of seats. Trying to sell all of the seats at the same price is very difficult to do especially when the airlines needed to at least be able to cover fixed operating expenses. A lot of times the planes would be left with empty seats, which, doesn’t help the airlines make any money. So by a... ...hould not be. Alan Campbell who has been working in the hotel industry for over thirty years believes that there should be more that goes into Revenue Management than just what the computer tells us. Campbell states, â€Å"Revenue managers need to have a feel for the system, not how it works, but what it does, and how it does it.† In other words a Revenue Manager must know all of the events happening in the area as well as all of the other venues in the area. They must have an instinct for knowing if the numbers are right and will bring the hotel the best property rates. Campbell’s views and ideas are something that is spreading within the Hospitality Industry, because when you are aware of the â€Å"human factor† as he calls it, properties are able to increase their Revenue per available room (Revpar), and occupancy percentages, above what the software will predict.

Followers and Leaders of Animal Farm

Animals on Manor Farm over throw their mean and evil rulers who have overworked and mistreated them. Once the animals get control over the farm they set up slogans and rules the animals must follow in order to have equality and justice on the new farm.The farm is mainly ran by the pigs, who are considered the most intelligent, and also the two main ruler pigs named Snowball and Napoleon. Napoleon uses dogs he took away as pups and trained them to follow his words and also uses them to chase Snowball off the farm. Now Napoleon has complete control over the farm along with the other pigs and the dogs.Napoleon’s number one pig who helps him run the farm the way he likes is named Squealer. Squealer is very persuasive and can manipulate any animal he needs to. The author of the book Animal Farm is named George Orwell and he wrote this story to have a allegorical representation of the Russian Revolution. Orwell shows in this piece of writing that both leaders and followers in a soci ety can act in ways that destroy certain rights such as freedom and equality. One of the followers name is Boxer and this horse believes that everything the pigs say about napoleon is always right.Overall, Napoleon’s right hand pig, Squealer, uses persuasive wording and powerful speeches to manipulate other animals on the farm that Napoleon is always right. In Animal Farm one of the leaders name is Squealer and he is a pig who is very persuasive.The text states, â€Å"The others said of Squealer that he could turn black into white. † (pg:16) When George Orwell describes Squealer as being able to â€Å"turn black into white†, he is in fact referring to Squealer's persuasive skill. In other words, Squealer has enough persuasive talent to be able to convince the animals in Animal Farm that black is white or vice-versa.Squealer uses his wonderful way of talking persuasively towards the other animals on the farm. When Squealer does this he is being manipulative words to make the animals think what he wants them to.This effects the equality on the farm because the animals may not realize that they are being cheated out of their rights they originally fought for when they ran the original farm hands off the farm. Squealer’s persuasion is powerful because he influences the animals into thinking only positive ideas about Napoleon. This shows that Squealer is very manipulative and takes advantage of his power of manipulation.Squealer keeps his power throughout the novel is by staying as an important aspect to Napoleon. Napoleon uses Squealer to go out and persuade the animals on the farm that the pigs aren’t doing anything wrong or against the rules. This is very relevant to the story because if Napoleon didn’t have Squealer to help him run the farm than Napoleon wouldn’t have too many supporters and without his supporters he wouldn’t have any power. In Animal Farm, Orwell chose the characteristics of the animals t o allegorically represent people or groups from the Russian Revolution.Napoleon plays Stalin who was a cruel ruler who used military tactics to enforce his rules. This overall represents how in Animal Farm Orwell used all of the characters to have an allegorical meaning. Squealer is a representation of the Propaganda Department, and Napoleon represents the Russian Revolutions cruel leader. Squealer’s overall goal is to persuade all of the animals to becoming loyal to Napoleon like how the propaganda department was a way of persuading the people of the Soviet Union to become loyal to Stalin.Squealer is reaching his goal one by one and gains support every time he talks to the animals. Next, in Animal Farm one of the animals who follow Napoleon and Squealer’s words is a very strong and hardworking horse named Boxer. At first, things seem to be going well. He's a hard worker, making â€Å"I will work harder† into his personal motto (ch-3). He's a brave fighter, and the narrator tells us that, during the Battle of the Cowshed, â€Å"the most terrifying spectacle of all was Boxer, rearing up on his hind legs and striking out with his great iron-shod hoofs like a stallion† (ch-4).But it's not enough to keep him safe. At the beginning of the novel, Old Major warns Boxer that he's disposable: â€Å"the very day that those great muscles of yours lose their power, Jones will send you to the knacker, who will cut your throat and boil you down for the fox-hounds† (ch-1). Boxer can see that—but once Jones is forced off the farm, Boxer thinks the threat is gone. He's just not smart enough to see that he's got a whole new species to worry about. Boxer worries about the farm, but he's not smart enough to figure things out on his own.Instead of thinking for himself, he decides to be loyal no matter what—to follow the Party (as in, Communist Party) line. Like, after Snowball is sent into exile, Boxer tries to think things over for himself, but all he can come up with is, â€Å"If Comrade Napoleon says it, it must be right,† and he takes up a new personal motto: â€Å"Napoleon is always right† (ch-5). Boxer is one of the animals who is easily persuaded and this is why the pigs think of him as a powerful disciple. Boxer absorbs everything the pigs tell him.Boxer would work so hard that it would influence the other animals to want to start and work also. This is not a good thing that is happening because when they are working on different projects on the farm they are taking orders from Napoleon and if they do that than there isn’t equality because this means that Napoleon is of a higher authority. If Napoleon is a higher rank in the social class than there isn’t equality. Boxer does not realize that he is giving up his freedom and he certainly doesn’t know that he is causing the other animals to also.He doesn’t realize this because all he does is follow Napoleons rules and work as hard as he can. Boxer motivates the other animals to work harder when the animals see him trying so hard to work. Boxer’s behavior is not typical of the animals on Animal Farm because he doesn’t ever question Napoleon like some of the other followers on the farm have. Also Boxer is not like the other animals because even though he is a follower he influenced other animals to follow in his footsteps and work harder.This shows that because Boxer is listening to Squealer he worked harder and that influences the other animals to work but also to give away their right to freedom and equality. In Conclusion, Napoleon’s second in command, also known as Squealer, persuades the animals on Animal Farm into thinking he is a wonderful leader. One of Squealer’s followers is a very work dedicated horse named Boxer. The author of this story is name Orwell and his purpose of writing this piece was to have the allegorical purpose of symbolism of the Russian R evolution.Orwell may have written this as a warning to the readers about how human behavior is when they get to much power. When someone gets too much power it goes to their head and they can’t function like they use to and may make bad decisions. From this novel the reader has learned that society is always adjusting itself. Not every situation is perfect nor can one expect perfection. However, the reader also learned that people have morals by which they hold themselves. Any leader who pushes his morals upon a group does not deserve power.

Benazir Bhutto Essays

Benazir Bhutto Essays Benazir Bhutto Essay Benazir Bhutto Essay He looked at her and smiled. Then looked outside and said those people. your people Li desolate and labor to give you an instruction. You owe them something. so you must come back and function these people. Benazir was raised to talk both English and Urdu but spoke Urdu conversationally at place instead. English was her first linguistic communication and while she was fluent in Urdu. it was neer grammatical. After her early instruction in Pakistan. she entered a more liberalist epoch in her life. She decided to prosecute her higher instruction in the United States while it went through daze of a cultural revolution. She attended Harvard University from 1969 to 1973. where she graduated cum laude awards with a grade in comparative authorities. During her clip in the United States she saw young person of every genre and walk of life imploring for a voice. imploring for equality. She saw the resiliency in the eyes of adult females commanding reform. justness and regard and began to follow their voice. She left the United States with the resiliency of Dr. King and the voice of Elizabeth Stanton. She subsequently described her clip at Harvard as the four of the happiest old ages of her life and said it formed the very footing of her belief in democracy. Benazir male parent. Prime Minister Zulfikar Ali Bhutto. was removed from office by the so head of ground forces General Muhammad Zia-ul-Haq following a military putsch in 1977. Zia imposed soldierly jurisprudence but promised to keep elections within three month but alternatively of carry throughing the promise of democracy. General Zia charged Zulfikar Bhutto with cabaling to slay the male parent of his opposing politician Ahmed Raza Kasuri. Benazir and her household fought the hawkish absolutism of General Zia-ul-Haq. despite effects to themselves for opposing soldierly jurisprudence. Benazir Bhutto and her brother Murtaza spent months in and out of house apprehension while she worked to coerce General Zia-ul-Haq to drop slaying charges against her male parent. They filed a request for the reconsideration the sentence of Zulfikar Bhutto. and for his release. However. General Zia-ul-Haq claimed to hold misplaced the request. and farther ignored world-wide entreaties for mildness. Benazir visited her male parent adamantly promising justness. freedom. Sadly Zulfikar Bhutto was hanged on April 1979. she was non able to see her male parent before his executing and regretted neer stating adieu. After the hanging of Zulfikar. Benazir and Murtaza were arrested repeatedly on frivolous charges. Nevertheless the PPP continued to win among the people. Following PPP’s triumph in the local elections. General Zia postponed the national elections indefinitely and moved Benazir. Murtaza. and their female parent to Larkana Central Jail. After repeatedly puting them under house apprehension. the government eventually imprisoned Benazir under lone parturiency in a desert cell at Sindh Province. She described the heat. the darkness. the bars and the annoyance of the sweet cell with a shuddering fright. Her confrontation with unfairness gave her the resiliency she needed to last the following phase of her life. After her imprisonment she was allowed to return to the United Kingdom in 1984 and became a leader in expatriate of the People’s Party of Pakistan. For the first clip in the history of Pakistan a adult female was caput of a major political party. though she was unable to do her political presence felt in Pakistan until after the decease of General Zia-ul-Haq. She still led a pro-democracy resistance to the General Zia-ul-Haq government even in expatriate. Continual success of the People’s Party of Pakistan allowed Benazir to go the 11th Prime curate. During her clip as premier curate. the effects of General Zia’s domestic policies began to uncover themselves and she found them hard to counter. Her platform during her first term was to revoke the controversial Hudood Ordinance and to return to the Constitution of Pakistan. Benazir Bhutto besides promised to switch to a Parliamentary system. But none of the reforms were made and Benazir began to fight with conservative President Ghulam Ishaq Khan over the issues of executive governments. President Khan repeatedly vetoed proposed Torahs and regulations that would hold lessened his Presidential authorization. Benazir’s merely accomplishments during her first term were enterprises for nationalist reform and modernisation which was viewed as Westernization. Her 2nd term on the other manus was highly different. She learned greatly from her errors during her first term and appointed a president that agreed with her positions leting her call to Westernization and democracy a batch more outstanding. After her 2nd term she was sent to Saudi Arabia in expatriate while her hubby. resembling the destiny of Benazir’s male parent. was arrested on false charges. He was charged with engagement in the decease of Benazir’s brother and was blamed for this calamity. After old ages in expatriate she returned to Pakistan to go on reform toward democracy. She said the Pakistan zephyr on her face was something she had missed as she left the plane. She was assassinated on December 7 2007 by an al-Qaeda-linked activist group after go forthing a mass meeting. Even with gunfires firing and bombs in the background she still stood tall and smiled merrily cognizing she was functioning her people.

The Tuskegee Syphilis Trial essays

The Tuskegee Syphilis Trial essays In 1932, The America Government conducted a study of a group of 399 young healthy black males who were part of an U.S. Public Health Service experiment of black men in the late stages of syphilis. The men in the experiment for the most part were illiterate sharecroppers from one of the poorest counties in Alabama, and they were never told of what disease they were suffering from or of its seriousness. Informed that they were being treated for bad blood, their doctors had no intention of curing them of syphilis at all. The information for the experiment was to be collected from autopsies of the men, and they were deliberately left to degenerate under the ravages of tertiary syphilis. Tertiary syphilis can include heart disease, tumors, paralysis, blindness, insanity, and death. The theory behind the study was that whites experienced more neurological complications from syphilis whereas blacks were more susceptible to cardiovascular damage. At the end of the experiment only 28 of the men had died directly of syphilis, 100 had died from related complications, 40 of their wives had been infected, and 19 of their children had been born with congenital syphilis. The PHS had offered the men incentives to participate in this study: free physical examinations, free rides to and from the clinics, hot meals on examination days, free treatment for minor ailments, and a guarantee that a burial stipend would be paid to their survivors. This modest stipend of $50.00 represented the only from of burial insurance that many of the men had. With this movie based on the true story of Tuskegee Syphilis Trial, it touched much deeper emotions inside myself. While watching this video I was in shock to see what our government did to its own people. I had just found a new respect and trust for our country from my Constitutional Law class the previous term, and most of that was all gone by the end of the video. This was a textbo...